Final answer:
The primary reason signaling molecules are not received by every cell nucleus is because some signal-receiving cells may lack the correct receptors.
Step-by-step explanation:
The primary reason the signaling molecule is not received by every cell nucleus is because signal-receiving cells may lack the correct receptors. Receptors are proteins that bind to signaling molecules and initiate a response in the target cell. Each cell has a variety of receptors, allowing it to respond to different stimuli. Some receptors can bind several different ligands, but typically, a receptor will only bind to its specific ligand. Therefore, if a cell does not have the receptor for a specific signaling molecule, it will not receive the signal.