Final answer:
The Columbian Exchange had a negative impact on the indigenous people due to the introduction of diseases from Europe, resulting in a significant depopulation.
Step-by-step explanation:
The question is about the negative impact of the Columbian Exchange on the indigenous people. The Columbian Exchange refers to the exchange of goods, animals, plants, and diseases between the Eastern and Western Hemispheres after Christopher Columbus's arrival in the Americas in 1492. While goods and resources flowed in both directions, diseases brought by the Europeans had a devastating impact on the indigenous population. Diseases such as smallpox and influenza, to which the Native Americans had no resistance, caused significant depopulation, with as much as 95% of the indigenous population being wiped out.