Final answer:
A governmental agency like Health and Social Services often leads in Health Information Exchange through RHIO development on a state level, leveraging their ability to align various stakeholders and provide adequate oversight and funding.
Step-by-step explanation:
According to the lecture, the entity that frequently became the leader in Health Information Exchange (HIE) through Regional Health Information Organizations (RHIOs) development on a state level is most likely a governmental agency like Health and Social Services. This is because governmental agencies often have the capacity to lead such initiatives, given their ability to coordinate multiple stakeholders and provide the necessary oversight and funding. Examples of this include the Medicaid program, which is a joint federal and state effort that provides health care to those with low incomes, and federally funded research groups like the National Institutes of Health (NIH), which have been leading sponsors of medical-related research.