Final answer:
The coefficient of the first term indicates that the left and right ends point in opposite directions.
Step-by-step explanation:
The part of the function that indicates that the left and right ends point in opposite directions is d) the coefficient of the first term.
In the given function, f(x) = 8x^3 - 3x^2 - 5x + 8, the first term has a positive coefficient of 8.
When the coefficient of the first term is positive, the graph of the function points upwards at the left end and downwards at the right end, indicating opposite directions.