Final answer:
The major issues in George W. Bush's second term included unsuccessful attempts to reform Social Security and limit medical malpractice lawsuits, challenges in Iraq, poor handling of Hurricane Katrina, and the onset of a severe economic crisis.
Step-by-step explanation:
During George W. Bush's second presidential term, major issues included domestic concerns, international conflicts, and natural disasters. Domestically, Bush's agenda of partial privatization of Social Security and imposing new limits on court-awarded damages in medical malpractice lawsuits faced significant obstacles. Internationally, Bush's aim to end tyranny faced difficulties, particularly with the ongoing challenges in Iraq. The Hurricane Katrina disaster in 2005 highlighted the limitations of the federal government's response capacity and further complicated Bush's tenure. Furthermore, Bush's administration contended with the onset of the most severe economic crisis since the Great Depression, leading to widespread dissatisfaction and the loss of popularity.
President Bush's second term also encountered criticisms for a perceived detachment from common people, as exemplified by his response to Hurricane Katrina. The pressing economic conditions, including a large federal deficit caused by tax cuts and the contentious war in Iraq, diminished public support for Bush's policies and ultimately led to significant political shifts, with the Democrats gaining control of Congress in the 2006 midterm elections.