Final answer:
The first large-scale slave uprising in America was the Stono Rebellion that took place in South Carolina in 1739. It was a key event that highlighted the continuous struggle for freedom among the enslaved population, leading to other significant revolts like the German Coast Uprising and Nat Turner's Rebellion.
Step-by-step explanation:
The first large-scale slave uprising in America was known as the Stono Rebellion. This significant insurrection occurred in South Carolina in September 1739 and was orchestrated by a literate Angolan named Jemmy, who along with a group of captive Africans, launched an armed revolt against White colonists. Although the militia eventually suppressed this uprising, with both the rebels and militiamen killed in battle, the event was a pivotal moment in pre-revolutionary America and underscored the desperate quest for freedom by those enslaved.
Furthermore, several other major slave uprisings preceded the Civil War. These include the German Coast Uprising in 1811, led by Charles Deslondes in Louisiana, and Nat Turner's Rebellion in 1831, in Virginia, revealing a pattern of continuous resistance against the institution of slavery. The Haitian Revolution also had a profound impact by displaying a successful overthrow of the White planter class, inspiring enslaved people in the Americas to fight for their freedom.