Final answer:
Rho-dependent termination is a process in prokaryotes where transcription is terminated when the protein rho disrupts the RNA:DNA hybrid region. It does so by breaking the hydrogen bonds between the RNA and the template DNA strand.
Step-by-step explanation:
Rho-dependent termination is a process in prokaryotes where transcription is terminated by an interaction between the RNA polymerase and a protein called rho. Rho disrupts the RNA:DNA hybrid region by breaking the hydrogen bonds between the RNA and the template DNA strand. This prevents further transcription.