Final answer:
Lactic acidosis can result from a deficiency of Thiamin (vitamin B1), as it is crucial for carbohydrate metabolism, and the lack of it leads to the accumulation of lactate, particularly affecting brain cells. The correct option is 3.
Step-by-step explanation:
Lactic acidosis can be a result of vitamin deficiency, specifically a deficiency in Thiamin (vitamin B1). Thiamine deficiency impairs the utilization of carbohydrates, leading to the accumulation of pyruvate and lactate in cells.
This effect is more pronounced in brain cells compared to skeletal muscle, as the blood-brain barrier in rats becomes permeable to pyruvate under thiamine-deficient conditions. Furthermore, erythrocyte transketolase levels are lower than normal in this scenario, indicating a functional deficiency of thiamine.
Metabolic acidosis, which includes lactic acidosis as a subtype, can also occur due to several other physiological and medical conditions. However, in the context of vitamins and lactic acidosis, thiamine plays a pivotal role in carbohydrate metabolism and the prevention of lactate accumulation. The correct option is 3.