Final answer:
Presence of two major features is sufficient to make a diagnosis of TSC
Two major features are sufficient for a diagnosis of Tuberous Sclerosis Complex, a genetic disorder with various potential growths in organs. Diagnosis combines clinical findings and genetic testing.
Step-by-step explanation:
The presence of two major features is sufficient to make a diagnosis of Tuberous Sclerosis Complex (TSC). TSC is a genetic disorder that can cause growths in various organs of the body, including the skin, brain, kidneys, and heart. Diagnosis is typically based on a combination of clinical findings and genetic testing.
Major features associated with TSC include skin abnormalities like hypomelanotic macules, facial angiofibromas, or shagreen patches; neurologic manifestations such as cortical dysplasias, subependymal nodules, and seizures; renal angiomyolipomas; and cardiac rhabdomyomas.