Final answer:
Tuberous Sclerosis Complex is a neurocutaneous disorder often caused by de novo mutations, but it can be inherited in an autosomal dominant pattern. If one parent is heterozygous for TSC, there is a 50% chance of passing the disorder to the offspring.
Step-by-step explanation:
Tuberous Sclerosis Complex (TSC) is a neurocutaneous disorder. It is indeed transmitted genetically – typically in an autosomal dominant pattern which means that if a parent has TSC there is a 50% chance of passing it on to their offspring if they are heterozygous (Nn).
However, around two-thirds of TSC cases are due to de novo mutations, meaning that they occur spontaneously and are not inherited from a parent. With regard to neurofibromatosis, which is also mentioned in the provided information, 50% of the second generation being dominant (Nn) indicates that they have inherited neurofibromatosis which suggests an autosomal dominant pattern of inheritance for this condition as well.