Question

2,4-Dinitrophenol (DNP) is known as an electron chain decoupler in the mitochondria and has a slimming effect. However, because it is dangerous and due to the occurrence of lethal cases, its use as a medicine is prohibited in several countries. In the mitochondria, this substance captures, in the intermembrane space, protons (H +) from the activity of respiratory chain proteins, returning them to the mitochondrial matrix. Thus, these protons do not undergo enzymatic transport, in the inner membrane. The slimming effect of this compound is related to:

A) obstruction of the respiratory chain, resulting in greater cellular consumption of fatty acids.
b) blocking the reactions of the Krebs cycle, resulting in greater cellular energy expenditure.
c) decrease in the production of acetyl CoA, resulting in higher cellular expenditure of pyruvate.
d) inhibition of ATP glycolysis, resulting in greater cellular expenditure of nutrients.
e) reduction of ATP production, resulting in greater cellular expenditure of nutrients.

Answer 1

The slimming effect of 2,4-Dinitrophenol (DNP) is related to the reduction of ATP production, resulting in greater cellular expenditure of nutrients.

Step-by-step explanation:

2,4-Dinitrophenol (DNP) is an electron chain decoupler in the mitochondria and it captures protons (H +) from the activity of respiratory chain proteins, preventing their transport in the inner membrane. This leads to a reduction in ATP production, resulting in greater cellular expenditure of nutrients. Therefore, the slimming effect of DNP is related to the reduction of ATP production, causing greater cellular expenditure of nutrients.