Final answer:
The cartoon drawn by Thomas Nast is against Boss Tweed, highlighting the corrupting power of money on politics.
Step-by-step explanation:
The political cartoon drawn by Thomas Nast, which depicts Boss Tweed with a moneybag for a head, is B. against Boss Tweed. Nast's cartoon is a critique of the corrupting power of money on politics and highlights the negative influence of Boss Tweed and his political machine. It is intended to bring attention to the issue and rally opposition against Boss Tweed and his practices.