Final answer:
Enzymes lower the amount of energy necessary to begin the reaction of glucose and oxygen during cellular respiration.
Step-by-step explanation:
The cell overcomes the need for a large energy input to begin the reaction of glucose and oxygen during cellular respiration by using enzymes.
Enzymes are biological catalysts that speed up the rate of chemical reactions by lowering the activation energy required for the reaction to occur. In the case of cellular respiration, enzymes lower the amount of energy necessary to begin the reaction of glucose and oxygen, making it easier for the reaction to start.