Final answer:
The difference between spot color and global color is their usage and flexibility. Spot color is a specific premixed ink used for accuracy, while global color is a color saved in a document's color swatches for easy modification and application throughout a design.
Step-by-step explanation:
The difference between the swatch appearance of a spot color and a global color lies in their usage and flexibility. A spot color is a specific ink that is premixed and used to achieve a particular color accurately. It is often used for logos and branding. On the other hand, a global color is a color that is created and saved in a document's color swatches and can be easily modified and applied to multiple elements. Global colors are commonly used for consistent color themes throughout a design.