Final answer:
The shingles vaccine safe to administer with TNF inhibitors is Shingrix, which is a non-live, recombinant vaccine. Live vaccines, such as Zostavax and Varivax, are not recommended for use with TNF inhibitors due to the risk associated with immune suppression.
Step-by-step explanation:
The shingles vaccine that is safe to administer with TNF (tumor necrosis factor) inhibitors is Shingrix. Shingrix is a non-live, recombinant subunit vaccine, which means it does not contain live varicella zoster virus, and is generally preferred for those with compromised immune systems, including people taking TNF inhibitors. This distinction is important because TNF inhibitors can weaken the immune system, making a live vaccine like Zostavax potentially unsafe.
Adacel is a vaccine against tetanus, diphtheria, and pertussis and is not related to the prevention of shingles. Zostavax, which was once used to prevent shingles, is a live vaccine and is not recommended for use with TNF inhibitors. Varivax is a vaccine for chickenpox (varicella), not shingles, and is also a live vaccine.
The varicella zoster virus is an enveloped virus that causes chickenpox initially and can later reactivate to cause shingles. Live vaccines are generally avoided in individuals taking TNF inhibitors because the immune suppression could potentially allow the live virus in the vaccine to cause disease. As such, the recombinant Shingrix vaccine is the preferred shingles vaccine in this situation.