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A provider wants to begin a patient on maintenance dosing for Temodar (temozolomide) and wants you to calculate the correct dose. You calculate the patient's BSA to be 1.67m2. What dose do you recommend?

1) 125.25mg (rounded up to 140mg capsule) - 1 capsule PO qday x 42 days
2) 250.5mg (rounded down to 250mg capsule) - 1 capsule PO qday x 5 days of a 28 day cycle
3) 125.25mg (rounded up to 140mg capsule) - 1 capsule PO qday x 5 days of a 28 day cycle
4) 250.5mg (rounded down to 250mg capsule) - 1 capsule PO qday x 42 days

1 Answer

4 votes

Final answer:

To accurately recommend a maintenance dose of Temodar (temozolomide), specific dosing guidelines based on clinical protocols and patient factors are needed, which are not provided in the question.

Step-by-step explanation:

The question involves the calculation of a maintenance dose of Temodar (temozolomide) based on the patient's Body Surface Area (BSA). The BSA of the patient is given as 1.67m2. However, to provide an accurate recommendation, we also need the standard dosing guidelines for temozolomide, which usually depend on the type of tumor being treated, the phase of treatment, and specific clinical protocols. Typically, temozolomide dosing is calculated based on BSA and adjusted according to the treatment plan, potentially including a loading phase followed by maintenance dosing. Without this additional information, including the protocol and phase of treatment, it is not possible to accurately recommend a dosing option from the choices provided. For accurate dosing, consult the current medical guidelines or prescribing information for temozolomide and consider patient-specific factors including prior treatment, renal and hepatic function, and potential drug interactions.

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