Question

Which of the following medications is considered a nucleoside reverse transcriptase inhibitor (NRTI)?

1) Prezista (darunavir)
2) Sustiva (efavirenz)
3) Tivicay (dolutegravir)
4) Vemlidy (tenofovir alafenamide)

Answer 1

Vemlidy (tenofovir alafenamide) is the correct answer as it is a prodrug of tenofovir, which is considered a nucleoside reverse transcriptase inhibitor (NRTI) used in the treatment of HIV/AIDS.

Step-by-step explanation:

Nucleoside Reverse Transcriptase Inhibitors, or NRTIs, are essential in the treatment of HIV/AIDS. They function by blocking the early step of converting viral RNA into DNA. AZT, also known as zidovudine, was the first drug of this class approved for the treatment of AIDS, and its mode of action is typical of this class of drugs. Most NRTIs are dideoxynucleosides, although there is one notable exception, tenofovir.

When considering the medications listed:

1. Prezista (darunavir) is a protease inhibitor.
2. Sustiva (efavirenz) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
3. Tivicay (dolutegravir) is an integrase inhibitor.
4. Vemlidy (tenofovir alafenamide) is a nucleoside reverse transcriptase inhibitor (NRTI), and a prodrug of tenofovir.

Therefore, the correct answer is Vemlidy (tenofovir alafenamide), which is considered a nucleoside reverse transcriptase inhibitor (NRTI).