Final answer:
An impulse returning to previously stimulated tissue typically happens during the refractory period when a neuron or muscle cell cannot generate another action potential and is transitioning back to its resting state.
Step-by-step explanation:
When an impulse returns to stimulate tissue that was previously depolarized, this generally refers to a phenomenon that occurs during or immediately after the refractory period. This refractory period is a critical phase immediately following the transmission of an impulse in a nerve or muscle, in which a neuron or muscle cell regains its ability to transmit another impulse. During a refractory period, the cell's membrane is momentarily unable to generate another action potential, allowing voltage-sensitive ion channels to return to their resting configurations. The sodium-potassium ATPase actively moves Na+ out of the cell and K+ back into the cell, resulting in repolarization, wherein the membrane returns to its resting state and can be depolarized again.
Specifically, the inrush of Na+ during depolarization neutralizes the inside of the membrane and may render it slightly positive. Afterward, the closure of Na+ channels and the outflow of K+ underpin repolarization, taking the cell back to its resting potential. In the context of the heart, this sequence of depolarization and repolarization is what enables the heart muscles to contract rhythmically, propelling blood throughout the circulatory system.