Final answer:
Bowing of the legs is the clinical manifestation associated with rickets, a childhood disorder characterized by bone deformities due to defective mineralization of bone caused by vitamin D deficiency.
Step-by-step explanation:
The clinical manifestation associated with rickets is bowing of the legs. Rickets is a childhood disorder characterized by bone deformities due to defective mineralization of bone, most commonly caused by deficiency of vitamin D. The lack of vitamin D leads to insufficient absorption of calcium and phosphate, resulting in soft and weak bones. Bowing of the legs is a common symptom of rickets, where the legs curve outward.