Final answer:
Fat-soluble toxins are poorly soluble in water due to their hydrophobic nature and have a lipophilic tendency, meaning they dissolve in fats and oils.
Step-by-step explanation:
The correct statement about the solubility of fat-soluble toxins and their lipophilic tendency is that these compounds have poor solubility in water due to their hydrophobic nature, meaning they are 'water-fearing'. Instead, they tend to be soluble in nonpolar substances like fats and oils because of their lipophilic (lipid-loving) properties. This makes them readily soluble in oil-based solutions and able to pass through the hydrophobic core of cellular membranes, which can facilitate their movement within the body's tissues. Therefore, none of the provided statements A, B, C, or D are accurate descriptions of fat-soluble toxins and their lipophilic tendency.