Final answer:
Tropomyosin is the key protein responsible for regulating muscle contraction in vascular smooth muscle.
Step-by-step explanation:
The key protein responsible for regulating muscle contraction in vascular smooth muscle is tropomyosin. In relaxed muscle, tropomyosin covers the myosin-binding sites on actin filaments, preventing muscle contraction. When calcium ions bind to troponin, it causes a conformational change in tropomyosin, exposing the myosin-binding sites and allowing for muscle contraction.