Final answer:
The two basic mechanisms to inactivate RTKs are Endocytosis and receptor degradation, and Desensitization and downregulation.
Step-by-step explanation:
The two basic mechanisms that can inactivate receptor tyrosine kinases (RTKs) are: Endocytosis and receptor degradation, and Desensitization and downregulation. Endocytosis and receptor degradation involve the internalization of the receptor from the cell surface and its subsequent breakdown within the cell. Desensitization often involves the phosphorylation of the receptor itself but in a manner that reduces its activity, and downregulation generally refers to a decrease in the number of receptors available on the cell surface, which can happen through various means, including endocytosis and degradation or reduced synthesis of the receptors.