Question

Griseofulvin demonstrates selective toxicity by :

A. inhibiting DNA synthesis of fungal DNA only
B. disrupting the mitotic spindle of fungi but not humans
C. blocking synthesis of a fungal cell wall
D. inhibiting synthesis of a fungal-specific ergosterol

Answer 1

Griseofulvin achieves selective toxicity by targeting and disrupting the mitotic spindle formation in fungi, without affecting human cells.

Step-by-step explanation:

Griseofulvin demonstrates selective toxicity by disrupting the mitotic spindle of fungi but not humans. This antifungal agent specifically interferes with fungal cell division by targeting the microtubules involved in spindle formation during mitosis, a cellular structure which is essential for proper chromosomal segregation. As human cells are not affected in the same way, griseofulvin creates a selective environment where it can hinder the growth and reproduction of fungal organisms without adversely impacting human cellular components.