Final answer:
Macbeth fears Macduff the most in Scotland, influenced by the prophecies and his own paranoia, which lead him to view Macduff as a significant threat.
Step-by-step explanation:
In William Shakespeare's Macbeth, the title character says that he fears Macduff the most out of all men in Scotland. Macbeth's fear stems from the Witches' prophecies and the growing suspicion and paranoia that haunt him throughout the play. Macbeth perceives Macduff as a threat to his throne, especially after Macduff refuses to attend Macbeth's coronation and displays a general distrust of Macbeth. This fear drives Macbeth to take extreme actions in an attempt to neutralize the threat he believes Macduff represents.