Final answer:
The correct punctuation for the sentence is option 2, which separates the independent clauses with a period.
Step-by-step explanation:
The correct punctuation for the sentence "She made everyday chores meaningful, when she set to work, hard and easy tasks alike were undertaken as acts of love" is option 2: "meaningful. When she set to work". This is because the second part of the sentence is an independent clause which should be preceded by a period or a semicolon when detached from another independent clause.
Option 1 is incorrect because the comma creates a comma splice. Option 3 is incorrect as it lacks a conjunction and does not address the comma splice. Option 4 repeats the error of option 1 and adds an unnecessary comma at the end.