Final answer:
The introduction of smallpox in the Americas had a devastating effect on the indigenous population, resulting in widespread death and suffering.
Step-by-step explanation:
When smallpox was introduced to the Americas by Europeans, it had a devastating effect on the indigenous population. The native inhabitants had no immunity to this disease, which led to widespread death and suffering. It is estimated that around 80 percent of the indigenous population perished as a result. The impact on the population was far worse than the Black Death in Europe.