Final answer:
Central sensitization in chronic pruritus refers to the phenomenon where the central nervous system becomes hypersensitive to itch signals, leading to prolonged and intensified itching sensations.
Step-by-step explanation:
Central sensitization in chronic pruritus refers to the phenomenon where the central nervous system becomes hypersensitive to itch signals, leading to prolonged and intensified itching sensations. It is a result of long-term exposure to repetitive and persistent itching stimuli, causing changes in the spinal cord and brain that amplify the itch response.
For example, in chronic pruritus, the nerve fibers in the skin may become sensitized, making them more responsive to itch-inducing substances. As a result, even mild stimuli can trigger a strong itch sensation. This hypersensitivity can make the chronic itching difficult to control and can significantly impact an individual's quality of life.