Final answer:
Topical cooling preparations alleviate symptoms of pruritus by providing a cooling sensation to the affected area and activating TRPM8 receptors.
Step-by-step explanation:
Topical cooling preparations, also known as cooling gels or creams, are a type of therapeutic intervention used to alleviate symptoms of pruritus (itching). These preparations function by providing a cooling sensation to the affected area, which can help to soothe the skin and reduce the sensation of itching. They work by activating specific receptors in the skin called TRPM8 receptors, which are sensitive to cold temperatures. When these receptors are activated, they can override the itching sensation and provide temporary relief.