Final answer:
Systemic manifestations of inflammation include fever, increased heart rate, increased respiratory rate, and changes in blood pressure.
Step-by-step explanation:
The systemic manifestations of inflammation include fever, increased heart rate, increased respiratory rate, and changes in blood pressure. Fever is a system-wide sign of inflammation that raises the body temperature and stimulates the immune response. Increased heart rate and respiratory rate are also commonly observed in systemic inflammation. Changes in blood pressure, such as an increase in systolic and diastolic pressures, can also occur.