Question

Based on the factors affecting absorption and rate-limiting how would you increase drug dissolution and increase the speed of absorption of oral medications?

Answer 1

To increase drug dissolution and speed up absorption of oral medications, factors such as increasing surface area, temperature, and modifying physiochemical properties should be considered.

Step-by-step explanation:

In order to increase drug dissolution and speed up absorption of oral medications, several factors can be considered:

1. Increasing the surface area of the drug particles can enhance dissolution. For example, grinding the medication into smaller particles increases the exposed surface area, allowing for faster dissolution.
2. Temperature can also play a role in increasing the speed of absorption. Heating up the solvent increases the kinetic energy of the molecules, leading to more frequent and forceful collisions between the solvent and solute, which results in faster dissolution.
3. Modifying the physiochemical properties of the drug, such as decreasing hydrophilicity or polarity, can improve permeability and passive diffusion. This can be achieved through formulation techniques.

By considering these factors, drug dissolution and absorption can be increased, leading to improved bioavailability of oral medications.