Question

Sickle Cell anemia is a disease caused by a recessive allele. What is the chance a child will have Sickle Cell if one parent has it, and the other parent does not and is homozygous?

A. 0%
B. 75%
C. 100%
D. 33%

Answer 1

In cases where one parent has sickle cell anemia and the other is homozygous normal, the offspring have a 0% chance of having the disease but a 50% chance of being carriers of the sickle cell trait.

Step-by-step explanation:

Sickle cell anemia is an autosomal recessive disorder caused by a mutation in the hemoglobin gene, resulting in abnormal hemoglobin that causes red blood cells to have a sickle shape. When one parent has sickle cell anemia (meaning they have two copies of the recessive allele) and the other is homozygous normal (meaning they have two copies of the unaffected allele), their children have a 0% chance of having sickle cell anemia but a 50% chance of being carriers.

This is because each child will inherit one sickle cell allele from the affected parent and one normal allele from the other parent, making them carriers (heterozygous for the trait).