Final answer:
Girolamo Cardano was an Italian mathematician who made three significant contributions to the field of mathematics, notably in probability, combinatorics, and algebra.
Step-by-step explanation:
Girolamo Cardano was an Italian mathematician who made significant contributions to mathematics. The correct statement regarding his contributions is that Girolamo Cardano made three major contributions to mathematics. These contributions include his work on the theory of probability, his establishment of the binomial coefficients, which are a fundamental component of combinatorics, and his development of Cardano's formula for solving cubic equations, which was a groundbreaking advancement at the time. Cardano was also a physician, philosopher, and gambler, which showcases the interdisciplinary nature of his work and the Renaissance period in which he lived.