Final answer:
Factors such as the spread of diseases, escalation of crime, and inadequate appreciation of leisure can hinder tourism development, with health risks and safety concerns being particularly impactful.
Step-by-step explanation:
The factors that hinder the development of tourism include the spread of diseases, escalation of crime, and inadequate appreciation of leisure. The spread of diseases can deter tourists due to health risks, as seen historically with the introduction of diseases such as measles and cholera by travelers in different parts of the world. The escalation of crime can make destinations less attractive due to safety concerns. While adequate publicity is not a hindering factor, and thus, not part of the correct answer, the risk of diseases and crime play a significant role in impacting the tourism industry negatively. An inadequate appreciation of leisure may deter local populations from engaging in or supporting tourism, though this is not typically a primary concern for the tourism industry.