Final answer:
The most effective revision of the run-on sentence is Option 1: Poor people do not want to stay poor forever or live in terrible conditions all of their lives; however, many are unable to rise above their circumstances.
Step-by-step explanation:
The most effective revision of the run-on sentence is Option 1: Poor people do not want to stay poor forever or live in terrible conditions all of their lives; however, many are unable to rise above their circumstances.
By using a semicolon instead of a comma, the two independent clauses are appropriately separated. This creates a clearer and more concise sentence structure, making it easier for readers to understand.