If you know your derivative rules, then
d/dx [1/x] = -1/x ²
so that when x = 6, the derivative has a value of -1/36.
If you have to use the definition of the derivative, then
d/dx [1/x] = lim {h → 0} (1/(x + h) - 1/x) / h
… = lim {h → 0} (x - (x + h)) / (hx (x + h))
… = lim {h → 0} (-h) / (hx (x + h))
… = lim {h → 0} (-1) / (x (x + h))
… = -1/x ²
and at x = 6, you again get -1/36.
Alternatively, use the definition of the derivative at a point:
d/dx [1/x] (6) = lim {x → 6} (1/x - 1/6) / (x - 6)
… = lim {x → 6} ((6 - x) / (6x)) / (x - 6)
… = lim {x → 6} -(x - 6) / (6x (x - 6))
… = lim {x → 6} (-1) / (6x)
… = -1/36