Final answer:
Joana likely has sickle cell anemia, a condition where defective hemoglobin causes red blood cells to be sickle-shaped and disrupt blood flow.
Step-by-step explanation:
Joana, a 12-year-old girl, who frequently suffers from cold, fever, and fatigue and has been found to have defective, misshapen molecules of hemoglobin, most likely suffers from sickle cell anemia. In sickle cell anemia, the abnormal hemoglobin S causes red blood cells to become sickle or crescent-shaped. These cells can block blood flow in narrow vessels, leading to symptoms such as high fever, severe pain, and fatigue. Sickle cell anemia is a genetic condition which decreases the blood's oxygen-carrying capacity, causing various complications.