Final answer:
The decreasing frequency of the sickle-cell allele in African Americans since malaria was eliminated in the United States is an example of natural selection.
Step-by-step explanation:
The decreasing frequency of the sickle-cell allele in African Americans since malaria was eliminated in the United States is an example of natural selection.
In regions where malaria is prevalent, individuals with the sickle-cell allele have an advantage as it provides protection against malaria. However, in areas where malaria is rare, such as the United States, carrying the sickle-cell allele does not provide any health benefits. As a result, over time, the frequency of the sickle-cell allele decreases in populations no longer exposed to malaria.
This phenomenon demonstrates how environmental changes can influence the frequency of alleles in a population through natural selection.