Final answer:
The liver is principally responsible for supplying glucose to the rest of the body when glucose reserves are low through the process of gluconeogenesis.
Step-by-step explanation:
Gluconeogenesis is the process of synthesizing new glucose molecules from smaller molecules such as pyruvate or lactate. This process primarily takes place in the liver when there is a low glucose level in the body. When glucose reserves are low, the liver synthesizes glucose through gluconeogenesis to maintain the blood sugar level and supply glucose to other organs, especially the brain which relies on glucose as an energy source.