Final answer:
Inosine of the tRNA anticodon can pair with uracil (U), cytosine (C), and adenine (A) in mRNA codons, due to the wobble hypothesis, allowing a single tRNA molecule to recognize multiple codons differing at the third position.
Step-by-step explanation:
The student is asking about what nucleotide bases the inosine (I) of the anticodon in tRNA can pair with. Inosine is a nucleotide that can pair with more than one base due to its unique structure, which allows for a relaxation of the base-pairing rules. This phenomenon is known as wobbling, referring to the flexibility at the third position of the mRNA codon and the corresponding base in the tRNA anticodon. Specifically, inosine can pair with uracil (U), cytosine (C), and adenine (A) on the mRNA codon, providing a means for a single tRNA to read multiple codons that differ in their third nucleotide. This is part of the genetic code's redundancy and allows for more efficient protein synthesis.