Question

Arrange details of the GPCR activation given a list of steps starting at the very beginning, which is binding of a hormone or neurotransmitter to a G-protein coupled receptor onward.?

Answer 1

GPCR activation occurs through hormone or neurotransmitter binding, causing shape changes in the receptor and subsequent activation of the G-protein. The G-protein subunits split, activate other proteins, and then reassociate to repeat the cycle.

Step-by-step explanation:

G-protein-coupled receptor (GPCR) activation occurs in a cyclic series of events. Here are the steps:

1. The hormone or neurotransmitter binds to a specific GPCR.
2. The receptor changes shape upon binding and recognizes the G-protein trimer on the cytoplasmic surface of the plasma membrane.
3. The G-protein trimer binds to the receptor, displacing GDP on the a subunit and replacing it with GTP.
4. The G-protein subunits split into the a subunit and the By subunit.
5. One or both of these subunits can activate other proteins.
6. The GTP on the active a subunit is hydrolyzed to GDP, and the By subunit is deactivated.
7. The subunits reassociate to form the inactive G-protein, and the cycle begins again.