Final answer:
When the K+ leak channel is closed, there is a decrease in the outward movement of K+ ions, resulting in a more positive membrane potential and potential depolarization of the cell.
Step-by-step explanation:
When the K+ leak channel is closed, the membrane potential is affected. The K+ leak channel is responsible for the continuous movement of K+ ions out of the cell, which helps maintain the resting membrane potential. When the channel is closed, there is a decrease in the outward movement of K+ ions, which can lead to a more positive membrane potential and depolarization of the cell.
For example, let's consider a neuron at rest with a negative membrane potential of -70 mV. When the K+ leak channel is closed, less K+ ions are leaving the cell, causing the membrane potential to become less negative or even positive. This change in potential can impact the excitability of the neuron and its ability to generate an action potential.
In summary, when the K+ leak channel is closed, there is a decrease in the outward movement of K+ ions, resulting in a more positive membrane potential and potential depolarization of the cell.