Final answer:
Inhibition of APC activation prevents a cell from exiting mitosis, as APC is crucial for the metaphase-to-anaphase transition. Inhibitors can also bind tubulin or prevent chromosome separation, thereby halting cell division and potentially inducing apoptosis if cell cycle checkpoints fail.
Step-by-step explanation:
The inhibition of APC (Anaphase Promoting Complex/Cyclosome) activation blocks exit from mitosis. This complex is responsible for triggering anaphase by marking key proteins for degradation, thereby allowing sister chromatids to separate and the cell to proceed with cytokinesis. When the activation of APC is inhibited, the result is that the cell cycle is halted at the metaphase-to-anaphase transition, preventing the conclusion of mitosis.
As for the function of APC inhibitors, they work in different ways, such as restricting the separation of chromosomes or binding the tubulin. This stops cell division by preventing proper microtubule functions that are essential during mitosis. Moreover, disruptions to APC can prevent vital cell cycle events, which may lead to the triggering of apoptosis if the cell fails to meet the required checkpoint criteria.
MP checkpoint, when compromised, can also inhibit the cell cycle, and there can be various reasons a cell fails to undergo apoptosis, such as mutations preventing the initiation of the apoptotic signaling pathway, loss of receptors, or overexpression of growth factor pathways that inhibit apoptosis.