Final answer:
The statement is false. Proteins tethering cadherins to the cytoskeleton are indeed related to signal transmission, as they play a role in cellular processes like signal transduction, adhesion, and maintaining tissue integrity.
Step-by-step explanation:
The statement that proteins involved in tethering cadherins to the cytoskeleton are unrelated to signal transmission is false. Proteins such as talin and vinculin not only tether cadherins to the cytoskeleton to form structures like desmosomes and adherens junctions, which are crucial for maintaining the structural integrity of tissues, but they also play a role in signal transmission. For instance, focal adhesions, which involve integrins and associated proteins, are important signaling centers that activate Rho-family GTPases. These signaling molecules then influence cellular processes such as cell migration, differentiation, and the actomyosin system's contractility. Thus, the tethering proteins are integral to both cell adhesion and signal transduction processes.