Final answer:
Cytoplasmic domains are connected to cytoskeletal actin filaments through interactions with transmembrane adhesion receptors called integrins. These integrins are crosslinked by cytoplasmic proteins like talin, which bind to actin filaments. Actin filaments can also interact with motor proteins like myosin to enable movement and contractility in cells.
Step-by-step explanation:
Cytoplasmic domains are connected to the cytoskeletal actin filaments through various mechanisms. One of the main mechanisms is through the interaction of the cytoplasmic domain of transmembrane adhesion receptors called integrins with actin filaments. These integrins are crosslinked by cytoplasmic proteins like talin, which in turn bind to actin filaments. This binding is further strengthened by proteins such as vinculin. Additionally, actin filaments can also interact with motor proteins like myosin, which allows for movement and contractility in cells.