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Describe the anticodon of a single tRNA that could recognize the codons 5'-AAC-3' and 5'-AAU-3'. How would this tRNA need to be modified for it to also recognize 5'-AAA-3'?

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Final answer:

The anticodon for recognizing codons 5'-AAC-3' and 5'-AAU-3' is 3'-UUG-5'. To also recognize codon 5'-AAA-3', it would need to include an inosinate (I) allowing for wobbling. In translation, a tRNA anticodon matches the mRNA codon, not the carried amino acid.

Step-by-step explanation:

The anticodon of a single tRNA that could recognize the codons 5'-AAC-3' and 5'-AAU-3' would be 3'-UUG-5'. Anticodons on tRNA are designed to be complementary to the codons on mRNA. Therefore, for the tRNA to also recognize the codon 5'-AAA-3', the first position of the anticodon (which is at the 3' end of the tRNA and pairs with the third position of the mRNA codon) would need to be inosinate (I), which can base pair with U, C, and A due to wobbling. The resulting anticodon would be 3'-UIG-5'.

Answering the quiz question, a. The anticodon will match the codon in mRNA, regardless of the amino acid bound by tRNA. This means that the tRNA's anticodon determines which mRNA codon it will pair with during translation, not the specific amino acid it carries after being chemically modified.

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