Final answer:
The 3' nucleotide of the anticodon on tRNA is indeed involved in wobble, which allows tRNAs to pair with multiple codons that differ in their third nucleotide position, contributing to efficient protein synthesis.
Step-by-step explanation:
The statement that the 3' nucleotide of the anticodon on the tRNA is involved in wobble is True. This wobble phenomenon allows for flexibility in the pairing between the third base of a codon in mRNA and the corresponding base in the anticodon of tRNA.
For instance, the base inosinate (I) in the anticodon can hydrogen bond with multiple nucleotide bases (U, C, and A), which explains how a single tRNA can recognize multiple codons that differ at the third position. This contributes to the efficiency and fidelity of protein synthesis during translation.