Final answer:
Integral proteins can have different orientations depending on their structure and function. They can span the membrane either once or multiple times, which affects their exposure to the inside and outside of the cell. The orientation is determined by hydrophobic and hydrophilic interactions.
Step-by-step explanation:
The orientation of integral proteins throughout transport can vary depending on their structure and function. Integral proteins can span the membrane either once or multiple times. If an integral protein spans the membrane once, it will have one side exposed to the outside of the cell and the other side exposed to the inside of the cell. If an integral protein spans the membrane multiple times, it can create channels or pores for the transport of molecules and ions. The orientation of the integral proteins is determined by the hydrophobic and hydrophilic interactions between the protein and the lipid bilayer.