Final answer:
Using gene transfer vectors for gene therapy can pose challenges such as triggering an inflammatory response, infecting unintended cells, reversion of the virus to being infectious, and unintentional deactivation of important genes in the patient's genome.
Step-by-step explanation:
Using gene transfer vectors for gene therapy can pose several challenges. One challenge is the risk of triggering an inflammatory response from the immune system, leading to organ failure. Another challenge is the potential for the virus vector to infect cells not targeted for therapy, causing harm to healthy cells. There is also a risk that the modified virus could become infectious again and cause disease in the patient. Additionally, there is a possibility that the inserted gene could accidentally deactivate an important gene in the patient's genome, which may disrupt normal cell cycling and potentially lead to tumor formation and cancer.
Because of these risks, candidates for gene therapy need to be fully informed of the potential hazards before proceeding with the therapy.