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How do vesicles fuse with other bilayers (destination compartments) in a cell? Describe the role of Rabs/Rab effectors and SNARE proteins in that process.

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Final answer:

Vesicles fuse with other bilayers in a cell through the binding of V-SNARE and T-SNARE proteins. Rabs and Rab effectors are involved in the targeting and tethering of vesicles to specific destinations, facilitating membrane fusion.

Step-by-step explanation:

Vesicles fuse with other bilayers (destination compartments) in a cell through the binding of V-SNARE (vesicle-SNARE) proteins on the vesicles to complementary T-SNARE (target-SNARE) proteins on the receiving membranes. This binding leads to the fusion of the membranes.

Rabs, also known as Rab GTPases, play a crucial role in the targeting and tethering of vesicles to specific destinations within the cell. They help recruit and activate effectors, which are proteins that facilitate vesicle fusion. Rab effectors, such as tethering factors, interact with both Rabs and SNARE proteins to promote membrane fusion.

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