Final answer:
When the ECM is destroyed, mammary gland epithelial cells may undergo changes in morphology and lose their normal function. Readding the ECM can help restore the cells' structure and interaction with the surrounding environment.
Step-by-step explanation:
When the extracellular matrix (ECM) is destroyed by matrix metalloproteinase or other enzymes, it can have a significant impact on mammary gland epithelial cells in culture. The ECM provides structural support, as well as biochemical signals, that are crucial for the survival and normal functioning of the cells. Without the ECM, the cells may undergo changes in morphology, lose their ability to adhere and migrate, and potentially undergo cell death.
If the ECM is readded back, it can provide the necessary cues to restore the normal behavior and function of the mammary gland epithelial cells. The ECM can guide cell adhesion, migration, and proliferation, and it can also influence cell signaling and gene expression. By reestablishing the ECM, the cells can regain their structure and restore their interaction with the surrounding environment.